The encoded protein (isoform 4) is shorter, compared to isoform 1. Status: REVIEWED Description Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. See identical proteins and their annotated locations for NP_001275998.1 Location: 210 → 561 SNF2_N SNF2 family N-terminal domain Location: 578 → 704 HELICc Helicase superfamily c-terminal domain associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases this domain is found in a wide variety of helicases and helicase related proteins may. This domain contains the ATP-binding region. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Location: 227 → 369 DEXDc DEAD-like helicases superfamily. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1. Status: REVIEWED Description Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and uses a downstream translation start codon, compared to variant 1. See identical proteins and their annotated locations for NP_001275997.1 Location: 226 → 623 SNF2_N SNF2 family N-terminal domain Location: 640 → 766 HELICc Helicase superfamily c-terminal domain associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases this domain is found in a wide variety of helicases and helicase related proteins may.
Location: 243 → 385 DEXDc DEAD-like helicases superfamily. The encoded protein (isoform 2) is longer, compared to isoform 1. Status: REVIEWED Description Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. See identical proteins and their annotated locations for NP_001275996.1
#IMAGEZILLA LSH DOWNLOAD#
NG_047057.2 RefSeqGene Range 5002.61313 Download GenBank, FASTA, Sequence Viewer (Graphics) This section to the one reported in Genomic regions, Identify version mismatches by comparing the version of the RefSeq in These reference sequences are curated independently of the genomeĪnnotation cycle, so their versions may not match the RefSeq versions in the current These reference sequences exist independently of genome builds. See citations in PubMed for homologs of this gene provided by HomoloGene Signal Transduct Target Ther, 2020 Sep 30. The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties.The DNA-helicase HELLS drives ALK(-) ALCL proliferation by the transcriptional control of a cytokinesis-related program.Lymphoid-specific helicase in epigenetics, DNA repair and cancer.Diagnostic, Prognostic, and Immunological Roles of HELLS in Pan-Cancer: A Bioinformatics Analysis.The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer.
Expression Broad expression in testis (RPKM 2.1), bone marrow (RPKM 1.7) and 22 other tissues See more Orthologs mouse all NEW Try the new Gene table Annotation information Note: The sequence defining GeneID 220513, which was based on XM_017508.4 and annotated on 12q13.12, currently corresponds to this locus.
Alternatively spliced transcript variants encoding different isoforms have been identified. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription.
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Full Name helicase, lymphoid specific provided by HGNC Primary source HGNC:HGNC:4861 See related Ensembl:ENSG00000119969 MIM:603946 AllianceGenome:HGNC:4861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as LSH ICF4 PASG SMARCA6 Nbla10143 Summary This gene encodes a lymphoid-specific helicase.
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